Monday, March 1, 2010

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Detecting infection in large-scale events

BOSTON (UPI) -- Researchers using real-time Internet-based surveillance said they determined no international infectious diseases posed a threat at the Vancouver Games.

Lead author Dr. John Brownstein of Children's Hospital in Boston and Dr. Kamran Khan of St. Michael's Hospital in Toronto say during the 1991 International Special Olympic Games in the United States, an outbreak of measles was triggered by an athlete from Argentina, where a concurrent measles epidemic was underway.

"This integrated knowledge could be used to notify officials at the site of the gathering of an emerging international threat, and could potentially foster a culture of greater international cooperation by motivating cities and countries that share common risks of infectious disease threats to work collaboratively," Brownstein and Khan said in a statement.

The researchers looked at historic patterns of international air traffic into Vancouver during February to predict where travelers would be originating from during the Winter Olympic Games. Travelers came from more than 800 cities worldwide, almost two-thirds traveled from 25 centers on which the researchers concentrated real-time infectious disease surveillance.

The authors integrated knowledge from BIO.DIASPORA and HealthMap -- two independent systems focusing on global air travel and infectious disease surveillance, respectively. No international infectious disease threats were identified that were deemed to pose a serious risk to the Winter Games, the study said.

The findings are published in the Canadian Medical Association Journal.

Copyright 2010 by United Press International

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New method kills prostate cancer cells

MELBOURNE (UPI) -- Australian biomedical scientists report they have identified a new way to treat prostate cancer.

Researchers at the Monash University in Melbourne used a drug compound to selectively activate the prostate's beta estrogen receptor cells. Study co-author Gail Risbridger says this has the effect of targeting for cell death a small but important population of cells in the prostate cancer tumor that are often resistant to conventional therapy and can lead to recurrent incurable disease.

"It is a significant piece of the puzzle that will help medical research in this field -- an achievement that could eventually enhance treatment options for patients around the world with advanced prostate cancer," Risbridger said in a statement.

Risbridger and colleagues used animal models to make the discovery and then replicated the results using human cells and tissues from patients with prostate cancer.

Risbridger said the studies provided proof of the controversial concept that estrogens -- hormones mainly thought to be important for women -- could be good for men and used therapeutically to treat prostate cancer.

The findings are published in the Proceedings of the National Academy of Sciences.

Copyright 2010 by United Press International

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Cholesterol screening should begin at 20

DALLAS (UPI) -- Although many may think heart disease is a middle-age worry a U.S. cardiologist suggests cholesterol screening should begin at age 20.

Dr. Anand Rohatgi, a cardiologist at the University of Texas Southwestern Medical Center in Dallas, says atherosclerosis -- hardening of the arteries -- begins early and young adults, and even teens, can show evidence of atherosclerosis.

If early screening reveals low levels of good high-density lipoproteins, or the "good" cholesterol, or moderately high levels of low-density lipoproteins, or the "bad" cholesterol, counseling can provide help to modify lifestyles. Those who fall into this category should be re-evaluated every one or two years, Rohatgi says.

"Simple measures that can reduce cholesterol levels include decreasing the amount of saturated fat to less than 7 percent of total calories consumed each day," Rohatgi says in a statement. "Also, increasing the amount of soluble fiber by just 5-10 grams daily and limiting cholesterol intake to less than 200 milligrams per day are helpful."

Copyright 2010 by United Press International

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Advanced prostate cancer may boost suicide

UPPSALA, Sweden (UPI) -- Swedish researchers found the suicide rate for men diagnosed with advanced or spreading prostate cancer is double that of the general male population.

Anna Bill-Axelson of the University Hospital in Uppsala, Sweden, and colleagues said the findings suggest a need to focus on identifying signs of depression and optimizing treatment for this category of patients.

The study, published in European Urology, found no evidence for an increased risk of suicide among men diagnosed with early prostate cancer detected by prostate-specific antigen testing. However, the researchers said the men in Sweden undergoing PSA testing may have been more health conscious than the general population, less prone to depression and more prepared to accept side effects.

The researchers looked at the number of suicides registered in cases of prostate cancer diagnosed between 1997 and 2006 in the Prostate Cancer Base Sweden -- a database in which a number of different registers are merged. They also looked at the suicide rate in the age-matched general male Swedish population.

The researchers found no evidence for an increased risk of suicide among men diagnosed with early prostate cancer detected by PSA testing.

Copyright 2010 by United Press International

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